Glossary
Every term in the canine longevity vocabulary
111 entries. Search by name or definition, filter by category, and tick any number of boxes to compare definitions side-by-side in the comparison drawer at the bottom of the page.
⌕
111 matches
A
AICARLifestyle
AICAR is a compound that mimics the effects of exercise at the cellular level and may influence longevity in dogs.
AMPKGeneral
AMPK, or AMP-activated protein kinase, is an important enzyme that helps regulate energy balance and metabolism in cells, including those in dogs.
AcarbosePharmacology
Acarbose is a carbohydrate-modifying drug that slows down the digestion of sugars, which can help manage blood sugar levels in dogs.
Addison's diseaseGeneral
Addison's disease in dogs is a hormonal disorder caused by insufficient production of adrenal hormones, particularly cortisol and aldosterone.
Akkermansia muciniphilaGeneral
Akkermansia muciniphila is a type of beneficial bacteria found in the gut that plays a role in maintaining gut health and overall well-being in dogs.
AntioxidantsBiology
Antioxidants are substances that help protect cells from damage caused by free radicals, which can contribute to aging and disease in dogs.
Atrial fibrillationGeneral
Atrial fibrillation is a heart condition characterized by an irregular and often rapid heartbeat, which can affect a dog's overall health and longevity.
AutophagosomeGeneral
An autophagosome is a specialized cellular structure that encapsulates and degrades damaged components within a cell, playing a crucial role in cellular maintenance and health.
AutophagyBiology
Autophagy is a natural cellular process that helps remove damaged components and recycle cellular materials, promoting overall health and longevity in dogs.
B
BCL-2 inhibitorsBiology
BCL-2 inhibitors are compounds that block the BCL-2 protein, which plays a role in regulating cell death, potentially promoting healthier aging in dogs.
BDNFGeneral
BDNF, or Brain-Derived Neurotrophic Factor, is a protein that supports the health and function of neurons in the brain and is believed to play a role in cognitive longevity in dogs.
BUN/creatinine ratioGeneral
The BUN/creatinine ratio is a laboratory measurement used to assess kidney function and overall metabolic health in dogs.
Beta-aminoisobutyric acidGeneral
Beta-aminoisobutyric acid is a naturally occurring compound that may support cellular health and longevity in dogs.
Biological ageBiology
Biological age refers to the physiological state of a dog’s body, reflecting its health and aging process rather than just the number of years lived.
C
Caloric restrictionLifestyle
Caloric restriction refers to reducing calorie intake without malnutrition, which has been shown to promote longevity and health in various species, including dogs.
Canine cognitive dysfunctionGeneral
Canine cognitive dysfunction is a neurodegenerative condition in dogs that leads to behavioral changes similar to dementia in humans.
Cellular reprogrammingGeneral
Cellular reprogramming refers to the process of reverting specialized adult cells to a more youthful, pluripotent state, potentially rejuvenating their function and extending healthspan.
ChaperonesGeneral
Chaperones are proteins that assist in the proper folding and maintenance of other proteins, playing a critical role in cellular health and longevity.
Chronic kidney diseaseGeneral
Chronic kidney disease (CKD) in dogs is a progressive condition where the kidneys gradually lose their ability to function effectively over time.
Chronological ageGeneral
Chronological age refers to the actual time that has elapsed since a dog's birth, measured in years.
Cognitive dysfunction syndrome (CDS) in dogs is a neurodegenerative condition that affects an older dog's cognitive abilities, akin to dementia in humans.
Cold exposureGeneral
Cold exposure refers to the practice of exposing dogs to lower temperatures, which may have potential benefits for their health and longevity.
Cruciate ligament ruptureGeneral
Cruciate ligament rupture refers to the tearing of one of the important ligaments in a dog's knee, which can lead to pain, instability, and long-term joint issues.
CurcuminGeneral
Curcumin is a natural compound found in turmeric that has anti-inflammatory and antioxidant properties, potentially benefiting canine health and longevity.
Cushing's diseaseGeneral
Cushing's disease, or hyperadrenocorticism, is a hormonal disorder in dogs characterized by an overproduction of cortisol, which can lead to various health issues.
D
DHAGeneral
DHA, or docosahexaenoic acid, is an omega-3 fatty acid that plays a crucial role in brain health and cellular function in dogs.
DNA methylationBiology
DNA methylation is a biological process that involves adding a methyl group to DNA, affecting gene expression and cellular function.
DasatinibBiology
Dasatinib is a medication primarily used in human medicine that has shown potential in veterinary research for its effects on aging-related diseases in dogs.
Diabetes mellitusGeneral
Diabetes mellitus in dogs is a chronic condition characterized by high blood sugar levels due to insufficient insulin production or response.
Dilated cardiomyopathyGeneral
Dilated cardiomyopathy is a heart condition in dogs characterized by the enlargement of the heart chambers and a weakening of the heart muscle, leading to reduced pumping efficiency.
E
EPAGeneral
EPA, or eicosapentaenoic acid, is an omega-3 fatty acid that can support overall health and longevity in dogs.
Elbow dysplasiaGeneral
Elbow dysplasia is a common skeletal condition in dogs characterized by abnormal development of the elbow joint, leading to pain and mobility issues.
Epigenetic clockBiology
The epigenetic clock is a biological measure that estimates the age of an organism based on DNA methylation patterns, which can indicate how well a dog is aging compared to its chronological age.
Exercise mimeticsLifestyle
Exercise mimetics are compounds that aim to replicate the beneficial effects of physical exercise on cellular and physiological health in dogs.
F
FOXO transcription factorsGeneral
FOXO transcription factors are proteins that play a crucial role in regulating cellular processes related to longevity and stress resistance in dogs.
FisetinPharmacology
Fisetin is a natural flavonoid found in various fruits and vegetables that has gained attention for its potential senolytic properties, which may help in promoting canine longevity.
Frailty indexGeneral
The frailty index is a measure used to assess the overall health and resilience of dogs, focusing on various biological markers and functional abilities.
G
GDF-11Biology
GDF-11, or Growth Differentiation Factor 11, is a protein that has been studied for its potential role in aging and tissue regeneration in various organisms, including dogs.
Geriatric screeningGeneral
Geriatric screening is a comprehensive evaluation process for older dogs to identify age-related health issues and optimize their care.
GeroscienceClinical
Geroscience is the study of the biological processes of aging and how they can be modified to extend healthspan and lifespan in various species, including dogs.
H
Hallmarks of agingBiology
The 'Hallmarks of aging' refer to a set of biological processes and changes that contribute to the aging of dogs and other organisms.
HealthspanGeneral
Healthspan refers to the period during which a dog remains healthy and free from serious age-related diseases.
Heart murmurGeneral
A heart murmur in dogs is an abnormal sound during the heartbeat caused by turbulent blood flow within the heart or its valves.
Heat shockGeneral
Heat shock refers to the cellular response triggered by elevated temperatures or stress, leading to the production of heat shock proteins that help protect and repair cells.
Heat shock proteinsBiology
Heat shock proteins are specialized proteins that help protect cells from stress, including the effects of aging and disease in dogs.
HemangiosarcomaGeneral
Hemangiosarcoma is a malignant tumor that originates from the blood vessels, commonly affecting dogs and often leading to serious health complications.
HematopoiesisGeneral
Hematopoiesis is the process by which new blood cells are formed in the body.
Hip dysplasiaGeneral
Hip dysplasia is a genetic condition in dogs where the hip joint doesn't fit properly into the hip socket, leading to arthritis and pain.
HormesisPharmacology
Hormesis is a biological phenomenon where a low dose of a potentially harmful stressor can have beneficial effects on health and longevity.
Hyperbaric oxygenGeneral
Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized environment, which can enhance healing and recovery in dogs.
HyperthyroidismGeneral
Hyperthyroidism in dogs refers to an overproduction of thyroid hormones, which can lead to various health issues.
HypothyroidismGeneral
Hypothyroidism in dogs refers to a condition where the thyroid gland does not produce enough thyroid hormones, which are essential for regulating metabolism and overall energy levels.
I
IGF-1Biology
IGF-1, or Insulin-like Growth Factor 1, is a hormone that plays a key role in growth and development, influencing aging processes in dogs.
InflammagingBiology
Inflammaging refers to the chronic, low-grade inflammation that often accompanies aging in dogs and can contribute to various age-related diseases.
Insulin sensitivityGeneral
Insulin sensitivity refers to how effectively a dog's body responds to insulin, a hormone that regulates blood sugar levels.
Intervertebral disc diseaseGeneral
Intervertebral disc disease (IVDD) is a condition where the discs between the vertebrae in a dog's spine degenerate or herniate, potentially leading to pain and mobility issues.
IrisinLifestyle
Irisin is a hormone produced by muscles during exercise that may play a role in regulating metabolism and promoting longevity in dogs.
iPSCGeneral
iPSC stands for induced pluripotent stem cells, which are adult cells reprogrammed to an embryonic-like state, enabling them to develop into various cell types.
K
KlothoBiology
Klotho is a protein that plays a significant role in regulating aging processes and is linked to longevity in various species, including dogs.
L
LifespanGeneral
Lifespan refers to the total duration of time an individual dog lives, influenced by genetics, environment, and health care.
Liver enzymesGeneral
Liver enzymes are proteins produced by the liver that help facilitate various metabolic processes, and their levels can indicate liver health in dogs.
LymphomaGeneral
Lymphoma is a type of cancer that originates in the lymphatic system, affecting lymphocytes, a kind of white blood cell, and is one of the most common cancers diagnosed in dogs.
LysosomeGeneral
Lysosomes are specialized cellular structures that break down waste materials and cellular debris in a dog's body.
M
Mast cell tumorGeneral
A mast cell tumor is a type of cancer that originates from mast cells, which are part of the immune system, and can vary significantly in behavior and appearance in dogs.
Maximum lifespanGeneral
Maximum lifespan refers to the longest period an individual dog can live under optimal conditions, determined by genetic and environmental factors.
Median lifespanGeneral
Median lifespan refers to the age at which half of a population of dogs is expected to live longer and half is expected to live shorter.
MelanomaGeneral
Melanoma is a type of cancer that originates in the pigment-producing cells called melanocytes, and it can occur in various parts of a dog's body, including the skin, mouth, and eyes.
MetforminPharmacology
Metformin is a medication commonly used to manage blood sugar levels in humans, and it is being studied for its potential benefits in promoting longevity and health in dogs.
Microbiome diversityGeneral
Microbiome diversity refers to the variety of microorganisms present in a dog's gut, which plays a crucial role in their overall health and longevity.
Mitochondrial dysfunctionGeneral
Mitochondrial dysfunction refers to a condition where the mitochondria, the energy-producing structures in cells, fail to function properly, impacting overall cellular health and energy levels.
MitohormesisGeneral
Mitohormesis refers to the phenomenon where mild stress on mitochondria can lead to improved cellular function and resilience, potentially enhancing longevity in dogs.
Mitral valve diseaseGeneral
Mitral valve disease is a common heart condition in dogs where the mitral valve becomes leaky, leading to heart failure over time.
mTOR pathwayPharmacology
The mTOR pathway is a cellular signaling pathway that regulates growth, metabolism, and aging in dogs and other organisms.
N
NAD+Pharmacology
NAD+ is a crucial coenzyme found in all living cells that plays a key role in cellular metabolism and energy production.
NMNBiology
NMN, or nicotinamide mononucleotide, is a naturally occurring compound that plays a crucial role in cellular energy production and is being studied for its potential effects on aging in dogs.
NavitoclaxGeneral
Navitoclax is a investigational compound that targets specific cellular pathways to promote healthspan and potentially extend longevity in dogs.
NeuroplasticityGeneral
Neuroplasticity is the brain's ability to reorganize itself by forming new neural connections throughout a dog's life.
O
Omega-3 fatty acidsGeneral
Omega-3 fatty acids are essential fats that play a crucial role in promoting overall health and longevity in dogs.
OsteoarthritisGeneral
Osteoarthritis is a degenerative joint disease characterized by the breakdown of cartilage, leading to pain and reduced mobility in dogs.
OsteosarcomaGeneral
Osteosarcoma is a type of bone cancer that is unfortunately common in dogs, particularly in larger breeds.
P
Pancreatic lipaseLifestyle
Pancreatic lipase is an enzyme produced by the pancreas that helps break down fats in the diet of dogs.
ParabiosisClinical
Parabiosis refers to the surgical joining of two living organisms, allowing them to share a circulatory system, often used in research to study aging and longevity.
Patellar luxationGeneral
Patellar luxation is a condition in dogs where the kneecap dislocates or moves out of its normal groove.
Plasma fractionsGeneral
Plasma fractions are components derived from blood plasma that can contain various proteins, hormones, and growth factors, which may play a role in promoting health and longevity in dogs.
PolyphenolsGeneral
Polyphenols are naturally occurring compounds found in plants that have antioxidant properties and may contribute to health benefits for dogs.
PostbioticsGeneral
Postbiotics are bioactive compounds produced by probiotics during fermentation, which can provide health benefits to dogs.
PrebioticsGeneral
Prebiotics are non-digestible food components that promote the growth and activity of beneficial gut bacteria, which can support overall health in dogs.
ProbioticsGeneral
Probiotics are live microorganisms that, when administered in adequate amounts, can provide health benefits to dogs by supporting their gut microbiome.
ProteostasisGeneral
Proteostasis refers to the balance and maintenance of proteins within cells, crucial for cellular health and function.
Pulmonary hypertensionGeneral
Pulmonary hypertension in dogs is a condition characterized by elevated blood pressure in the blood vessels of the lungs, which can lead to serious cardiovascular complications.
p16INK4aClinical
p16INK4a is a protein that serves as a biomarker for cellular aging and senescence in dogs and other animals.
p53General
p53 is a crucial protein that regulates the cell cycle and acts as a tumor suppressor, playing a vital role in preventing cancer in dogs and other animals.
Q
QuercetinGeneral
Quercetin is a natural flavonoid found in various plants that may have potential benefits for canine health and longevity.
R
RapamycinPharmacology
Rapamycin is a compound that has shown potential in extending lifespan and promoting healthspan in various organisms, including potentially dogs.
Reactive oxygen speciesBiology
Reactive oxygen species (ROS) are highly reactive molecules that can cause cellular damage and play a role in the aging process of dogs.
Renal insufficiencyGeneral
Renal insufficiency in dogs refers to a condition where the kidneys are unable to effectively filter waste products from the blood, leading to potential health complications.
ResveratrolBiology
Resveratrol is a natural compound found in certain plants, known for its potential anti-aging properties and effects on cellular health.
S
SarcopeniaGeneral
Sarcopenia in dogs refers to the age-related loss of muscle mass and strength.
SenescenceBiology
Senescence refers to the process of cellular aging, where cells lose their ability to function properly and contribute to the overall decline in health.
The senescence-associated secretory phenotype (SASP) refers to a collection of factors secreted by aging or damaged cells that can negatively impact surrounding tissues and overall health.
Senior wellness panelBiology
A senior wellness panel is a comprehensive set of diagnostic tests designed to assess the health and wellbeing of aging dogs.
SenolyticsBiology
Senolytics are compounds that selectively target and eliminate senescent cells, which contribute to aging and age-related diseases in dogs.
Short-chain fatty acidsGeneral
Short-chain fatty acids (SCFAs) are fatty acids with fewer than six carbon atoms, produced in the intestines during the fermentation of dietary fibers by gut bacteria.
SirtuinsBiology
Sirtuins are a family of proteins that play a crucial role in regulating cellular health, metabolism, and the aging process in various organisms, including dogs.
SpermidinePharmacology
Spermidine is a naturally occurring polyamine that has been linked to cellular health and longevity in various organisms, including dogs.
Stem cell exhaustionGeneral
Stem cell exhaustion refers to the decline in the number and functionality of stem cells in an organism, which can impact tissue repair and regeneration as dogs age.
T
TelomereBiology
Telomeres are protective caps at the ends of chromosomes that play a crucial role in cellular aging and longevity.
Thyroid panelGeneral
A thyroid panel is a blood test that measures the levels of thyroid hormones in a dog's bloodstream to assess thyroid function.
Time-restricted feedingGeneral
Time-restricted feeding is a dietary approach where dogs are fed during specific time windows each day, allowing for fasting periods that may promote health and longevity.
Y
Yamanaka factorsGeneral
Yamanaka factors are a set of four specific genes that can reprogram adult cells to a more youthful, pluripotent state, which may have implications for extending lifespan and improving health in dogs.
Young blood factorsGeneral
Young blood factors refer to biological substances found in the blood of younger animals that may promote health and longevity when introduced to older individuals.
We scour the web 4×/day.81 news articles indexed521 social posts analyzed40 vet practices tracked68 countries monitored